Nile tilapia (Oreochromis niloticus) and red tilapia (Oreochromis ssp.) are important aquaculture species in Vietnam. The aim of the current study was to assess the growth performance and feed utilization of Nile and red tilapias under different salinity conditions. The experiments were designed with salinities of 0, 15 and 25 ppt in 500-L tanks. The growth performance was evaluated using various indices, including weight gain (WG), specific growth rate (SGR), food conversion rate (FCR) and daily food intake (DFI). Results after a 55 days experiment showed that WG, SGR were highest at 0 ppt and lowest at 25 ppt for Nile tilapia while these values were highest at 25ppt and lowest at 0 ppt for red tilapia. The same pattern also observed for DFI. There were no significant differences for FCR among the treatments of Nile and red tilapias, except a significant high FCR was observed for Nile tilapia at 25 ppt. Possibility of Nile and red tilapias culture in saline water were discussed.