A study was conducted at Experimental Farm for Aquaculture, Nong Lam University in HCM City to determine nursing density and feeding rate for young red tailed catfish (Mystus wyckioides) at 3 to 30 days old stage. The study was replicated 4 times at the different time and there were 3 lots per treatment at the same time (3 replicates per treatment). The results of the study showed that: The growth of young fish of treatments fed 5 times per day was better than that of fish fed 4 times per day. When nursing with density of 4 fry per litter, the growth was better than that of nursing with density of 5 fry per litter. When nursing with density of 4 fry per litter and feeding of 5 times per day, the growth was the best (3.83 ± 0.05 cm; 0.56 ± 0.02 g). Nursing density and feeding rate did not impacted on survival rate and coefficient of variation of young red tailed cat fish.